Top South San Francisco Hotel Deals

Make the Most of Your South San Francisco Stay

The birthplace of biotechnology

South San Francisco has transformed from its meat-packing origins into the global epicenter of life sciences innovation, where over 200 biotech companies now occupy sleek glass campuses along the bay. The famous hillside sign reading "South San Francisco The Industrial City" still commands attention from Highway 101, a National Register landmark that tells the story of this evolution. Downtown's Grand Avenue maintains its historic character with family-owned businesses and authentic ethnic restaurants, while the waterfront Oyster Point district has emerged as the city's modern face—home to Genentech's headquarters and a marina with ferry connections across the bay.

Strategic access and authentic experiences

San Francisco International Airport sits immediately adjacent, making this an exceptionally convenient base for business travelers visiting the peninsula's biotech corridor. BART, Caltrain, and Oyster Point ferry provide multiple transit options into San Francisco or down to Silicon Valley. The Basque Cultural Center serves traditional family-style meals reflecting the area's heritage, while the 92-foot Wind Harp Tower at Genentech creates ethereal music when bay winds pass through its strings.

Natural escapes within reach

San Bruno Mountain State Park borders the city with rugged trails and 360-degree Bay Area views, while Sign Hill Park offers quick hiking with panoramic vistas. The San Francisco Bay Trail winds along Oyster Point's waterfront, perfect for morning runs. Half Moon Bay's dramatic coastline lies 20 minutes west, and Pacifica's surf breaks are even closer.

Frequently Asked Questions about South San Francisco

Can I use my miles on Delta Stays to book hotels in South San Francisco?

Yes, you can use your Delta miles to book your South San Francisco hotel stay, or you can combine your miles with cash for more flexibility. Simply log in to your SkyMiles® account, where you will also discover Member-only offers at select properties that could enhance your travel experience.

What is the benefit of booking my South San Francisco hotel directly on Delta Stays?

SkyMiles Members can earn 2 miles per $1 spent on completed hotel stays and vacation rentals booked through Delta Stays, get access to Member offers at select properties, and can pay with miles, cash, or a combination of both. To ensure you earn miles when paying fully with cash, simply sign in to your SkyMiles account or enter your SkyMiles number at checkout. Please allow up to 8 weeks after completing a stay for miles to appear in the SkyMiles account provided. Please also note that if you use miles to pay for any portion of your stay, you will not earn miles on that reservation, including any amount paid with cash.

Is it possible to change or cancel my hotel booking made through Delta Stays?

Cancellation policies differ depending on the property you choose. Be sure to check the cancellation policy listed under the hotel’s details before booking. Some rates are fully refundable while others are non-refundable. Any modifications or cancellations to your reservation may affect the number of miles you earn and receive in your account.

Can I use my Delta SkyMiles® American Express® Card to book?

Yes, your Delta SkyMiles® Gold, Platinum, or Reserve American Express® Card grants you additional miles and valuable benefits, including an annual credit of up to $200 on your statement applicable toward prepaid accommodation or vacation rental reservations made through Delta Cars and Stays. Please note that terms apply to these offerings. Learn more about your benefits at the Delta SkyMiles® American Express Credit Cards page.

Can I earn MQDs on Delta Stays hotel bookings?

Occasionally, Delta Stays may offer SkyMiles Members an opportunity to earn Medallion® Qualification Dollars on hotels and vacation rentals booked through Delta Stays. We recommend accessing the Delta Stays MQD Offer page to view current MQDs promotions and examine their terms and conditions.

Do I need to have a Delta SkyMiles account to book hotels on Delta Stays?

No, Delta Stays accommodations are accessible to all travelers seeking hotel reservations. Nevertheless, enrollment as a SkyMiles Member provides you with opportunities to accumulate miles and gain access to preferential pricing and promotions available only to Members. SkyMiles Members earn 2 miles per $1 spent on Delta Cars and Stays purchases (excluding taxes and additional fees). Enrollment in the SkyMiles program comes at no cost. Register today by going to the delta.com.

Can I book a vacation rental through Delta Stays?

Yes, in addition to traditional hotels, Delta Stays provides an extensive collection of vacation rentals for your vacation. You can explore a variety of homes, condos, and specialty lodging powered by Vrbo by visiting the Vacation Rentals page.

What hotels in South San Francisco have high ratings?

In South San Francisco, you’ll find 28 hotels to choose from when you book on Delta Stays. DoubleTree by Hilton San Francisco South Airport Blvd has a guest rating of 8.4 out of 10, and features a bar/lounge and a fitness facility. Another top-rated hotel is Embassy Suites by Hilton San Francisco Airport Oyster Point and guests love the free buffet breakfast. AC Hotel by Marriott San Francisco Airport Oyster Point/Waterfront has a rating of 9.2 and this hotel has an indoor pool and an ocean-view restaurant.

What is a good area in South San Francisco to book for my trip?

South San Francisco is home to a wide variety of fascinating neighborhoods loved by travelers and locals.

Oyster Point balances sleek biotech campuses with San Francisco Bay waterfront beauty, where modern glass buildings meet the Bay Trail's panoramic views and public art installations create visual interest along peaceful walking paths. One of the popular places to stay in the area is AC Hotel by Marriott San Francisco Airport Oyster Point/Waterfront.

What's a good time of year to visit South San Francisco?

To experience San Francisco during great weather, consider a visit in September when the temperature averages 68°F and the skies are mostly sunny with minimal fog. For off-peak prices and more deals on hotels, consider visiting during December when temperatures reach a cooler 52°F with occasional rain and the lowest visitor numbers of the year.

What hotels in South San Francisco are near See's Candies?

This American chocolate factory greets visitors with the rich aroma of fresh confections. Customize your own box of premium candies and enjoy a complimentary sample. Popular hotels include The St. Regis San Francisco which is a short drive away. Four Seasons Hotel San Francisco is another well-reviewed hotel and it is within a short drive.

What hotels in South San Francisco are located closest to San Bruno Point Park?

Point San Bruno Park offers sweeping views of San Francisco Bay where planes from SFO soar overhead. The waterfront trails provide a peaceful escape with ideal picnic spots. Popular hotels include AC Hotel by Marriott San Francisco Airport Oyster Point/Waterfront which is a 14-minute walk. The St. Regis San Francisco is another well-reviewed hotel and it is within a short drive.

What hotels in South San Francisco are located near K1 Speed San Francisco?

Race electric karts at speeds up to 45 mph on this professionally designed indoor track, where instant torque delivers thrills for first-timers and racing enthusiasts alike. The St. Regis San Francisco is a popular hotel, which is just a short drive away. Another top hotel is Four Seasons Hotel San Francisco and it is within a short drive.

*Terms and conditions:

Mileage Offer:

SkyMiles Members will earn two (2) miles per US$1 or equivalent foreign currency spent at https://carsandstays.delta.com/Opens in a new window on the base hotel rate for a completed hotel stay. Base hotel rate is the cost of the hotel room, before taxes and fees, charged at the time of booking or upon checkout. Taxes and fees, gratuities, room service other booking charges, or any bookings which are paid or reduced by miles, redemption vouchers or discount codes are excluded from mileage credit. For clarity, if miles are used as a form of payment (whether for all or a portion of the booking), no portion of the booking will be eligible to earn miles under this offer. Except with respect to the Hertz Mileage offer (listed below), SkyMiles Members will earn two (2) miles per eligible US$1 or equivalent foreign currency spent at https://carsandstays.delta.com/Cars on the base car rental rate for a completed car qualifying rental booking (“Qualifying Dollars”). A qualifying rental booking includes rentals at a participating location for one or more days at rates other than travel industry rates or discounts, wholesale of tour package rates or discounts, wholesale tour package rates, insurance/dealer replacement rates, corporate and government rates, group travel discounts, or rentals in conjunction with a frequent flyer car award, or other corporate agreements applicable to the respective car company. Calculation of the applicable standard mileage offer is listed below by car rental company. Qualifying Dollars include the base car rental rate, which is the cost of the car rental before taxes and fees, charged at the time of booking. Taxes, fees, other incidental charges, or other booking charges or any bookings which are paid or reduced by redemption vouchers or discount codes are excluded from mileage credit and are not included in the Qualifying Dollars.

This mileage offer does not apply to stays or car rentals booked through Delta Vacations or any cruises booked through Delta Cruises.

Standard mileage offer for car rentals booked at https://www.delta.com/Opens in a new window or https://carsandstays.delta.com/Opens in a new window:

Hertz Reservations:

• General SkyMiles Members earn 4 miles per Qualifying Dollar

• Silver Medallions earn 5 miles per Qualifying Dollar

• Gold Medallions earn 6 miles per Qualifying Dollar

• Platinum Medallions earn 7 miles per Qualifying Dollar

• Diamond Medallions earn 8 miles per Qualifying Dollar

Dollar and Thrifty Reservations:

• All SkyMiles Members earn 4 miles per Qualifying Dollar

Alamo, Enterprise, National, Avis, Budget, Payless and SIXT Reservations:

• All SkyMiles Members earn 2 miles per Qualifying Dollar